Peter Rogers, [09 Jul 2024 at 13:15:23]: Good afternoon all. Any thoughts on the use of water-based perphenazine (perphenazine hydrochloride /WBP) in cheetahs please? I accompanied 10 cheetahs on a long flight out of country last year and had a very bad reaction in 2 of them - hyperventilation, collapsed in crates and seemingly unaware of their surroundings. These are typical symptoms of a shock reaction, but these only started about 18 hours after administering WBP. I was convinced it was a reaction to this drug, but I also gave s/c drip using Hyalase at the same time as giving WBP 🤷♂️. I was convinced we would open the crates on the other side to two dead cheetahs, but they were absolutely fine – I cannot explain it. Any thoughts please and any adverse reactions experienced with WBP in cheetahs or other carnivores for that matter? Zoe Glyphis, [09 Jul 2024 at 14:32:18 (09 Jul 2024 at 14:32:30)]: Hi Pete. What's your WBP dose in these cheetah? I have used it intra-muscularly in many adults and subadults at reversal at between 6 and 12 mg total dose and have never had any issues. I have also administered it to many wild dogs at approximately 7 mg per adult also with no issues. I even double dosed one with 14 mg and it was also fine. Maybe a Hyalase reaction? I recall some possible potential for anaphylaxis with repeat Hyalase administration in rhinos? Peter Rogers, [09 Jul 2024 at 14:38:34]: Thank you, Zoe. If memory serves me correctly 0.3 mg/kg. I hear what you say about the Hyalase, but why only 18 hours later then, even if it was either of the two? Ulf Tubessing, [09 Jul 2024 at 15:26:00]: Hi Pete. An adverse reaction to WBP would be visible within 15-30 min. Maybe contaminated WBP? Peter Rogers, [09 Jul 2024 at 15:31:11]: I would have thought so
