[09:49, 23/05/2022] Gareth Hunter: A farrier in our area needs to do 4 horses that are completely wild. He wants me to dart them so it would be like a sedation so what do you recommend to use? I found an article that says medetomidine 0.015mg/kg, ACP 0.05mg/kg and butorphanol 0.02mg/kg but seems very high. For a 400kg horse that’s like 6mg medetomidine, 8mg acetylpromazine and 8mg butorphanol? [09:56, 23/05/2022] Douw Grobler: Hi Gareth. There are so many combinations you can rather use in my opinion. 1 to 2 mg M99 and 5 to 7 mg medetomidine and 40 to 60 mg azaperone works very well. If not deep enough, ketamine IV works wonders in 50 to 70 mg bolus doses.